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The key words consisted of either erinacine or Hericium erinaceus and (Neuroprotection or Neurotrophins or Neuron or Neuronal System)

Finally, a four-year, multicenter, clinical trial in 421 diabetic patients with distal symmetric sensorimotor polyneuropathy found no difference between oral administration of 600 mg/day of lipoic and placebo on the primary endpoint, a composite score that assessed neuropathic impairment of the lower limbs and nerve conduction (78)

In summary, given the high expression levels of METTL9 in mouse and human brain, as well as the neurodevelopmental phenotypes potentially related to its deletion in patients, we hypothesised that Mettl9 dosage could be important for sustaining early neural development