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A moderate, sustained approach over 3-4 months typically yields better results than aggressive short-term treatment

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FEBS J 281(6):15341546 McGonigal R, Barrie JA, Yao D, McLaughlin M, Cunningham ME, Rowan EG, Willison HJ (2019) Glial sulfatides and neuronal complex gangliosides are functionally interdependent in maintaining myelinating axon integrity

It also facilitates crosstalk with tumor-associated macrophages, particularly the M2 phenotype, to further dampen antitumor immunity

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