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To directly analyse the activity of the GSH biosynthetic pathway, we assayed, in cell extracts, the activity of GCL (the rate-limiting step in GSH biosynthesis)

As a result, the combination of erastin and JMF4073 both at sub-micromolar concentration acts synergistically to cause lethality in these blast-crisis CML cells

EMT processes might also be linked to both autophagy and ferroptosis in glioma

This attack leads to the activation of pro-apoptotic proteins like Bax while simultaneously suppressing anti-apoptotic factors such as Bcl-2, ultimately tilting the balance toward cellular demise

In the ischemia-reperfusion model of mice, compared with the wild type mice, the transgenic mice with super surface human Bcl-2 gene reduced the MI area and improved the ejection fraction (140)