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Furthermore, the possibility of generating human brain organoids from hiPSCs derived from patients (e.g., with a neurodevelopmental disease) allows in vitro modeling of several brain disorders (while maintaining the genomic context) (Sidhaye and Knoblich, 2021), which would contribute to the study and understanding of the mechanisms involved in mitochondrial diseases and neurodevelopmental disorders (Soldner et al., 2011)

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Interestingly, we observed no significant change in PAGly (Fig