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& Ecker, J

2214 Distribution of fluoxetine and its metabolites into human body tissues and fluids has not been fully characterized

This is supported by the RCT studies which showed a similar number of AEs in the placebo group to the treatment groups (Sandborn et al ., Reference Sandborn, Elliott, Weinstock, Summers, Landry-Wheeler, Silver, Harnett and Hanauer2013

This has lead to the use of alternate velocity equations which do not use the kinetic constants kcat and Km at all, instead depending on a different rate constant, (Toppo et al., 2009)