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The functional consequences of DNA methylation are highly context-dependent: MeCP2 binding to the methylated CpG island at the Dlx5 gene locus, involved in GABAergic neuronal differentiation, resulted in repression ( Dlx5 CpG sites in mouse models, concomitant with mitigated impairment of GABAergic neuronal differentiation (Liao et al., 2023)

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