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Thus, we can design miRNA mimics to overexpress miRNAs that down-regulate c-Met signaling pathways, and design miRNAs antagonists to inhibit miRNAs that up-regulate c-Met signaling pathways (Karagonlar et al., 2015)

KRAS can activate downstream factors through phosphorylation reactions, and ultimately promote cell proliferation by regulating signaling pathways such as the RAS-RAF-MEK-ERK and PI3K-AKT pathways 42

In comparison with the SA suspension, SA-SMEDDS showed significant prolonged T max , t 1/2 , and MRT after oral administration