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This type of injury is caused by events or illness such as stroke, transient ischemic attack (TIA), carbon monoxide poisoning, viral or bacterial infection, drowning, tumors, fever, and more

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More critically, this masking, although neither complete nor permanent, can permit neurologic dysfunction to develop and sometimes become irreversible

Second, as mentioned above, c-Met inhibitors which target the interaction between HGF and c-Met may lose efficacy owing to cell attachment (Wang et al., 2001), gene amplification of c-Met, DCP binding to c-Met (Suzuki et al., 2005), gene mutation in the c-Met activation loop (Okuma and Kondo, 2016) and crosstalk with other membrane receptors (Garcia-Vilas and Medina, 2018)

506,507 Nucleic acid oxidation products like 8-oxo-dG (8-oxo-2-deoxyguanosine) are commonly used biomarker for oxidative stress and DNA damage caused by ROS