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The concomitant use of opioids with other drugs that affect the serotonergic neurotransmitter system, such as selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, drugs that affect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), certain muscle relaxants (i.e., cyclobenzaprine, metaxalone), and monoamine oxidase (MAO) inhibitors (those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue), has resulted in serotonin syndrome [see PRECAUTIONS, Information for Patients/Caregivers]

In the context of liver-adipose tissue axis, elevated lipin-1 levels aggravate abnormal iron deposition and increases hepatic MDA levels in GPx4-independent manner, thereby aggravating alcoholic steatohepatitis and hepatobiliary injury [193]

Moreover, many studies have shown a clear connection between IGF-1 deficiency and metabolic syndrome

Y.OrekhovA

[Abstract]2019 Jan-Dec:33:2058738419857537