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They secrete large amounts of collagen and fibronectin, disrupt the basement membrane, and induce epithelial apoptosis, resulting in irreversible architectural distortion

Jannini EA, DeRogatis LR, Chung E, Brock GB

However, most of the results of pharmacological studies are derived from cellular or animal models, and they do not fully prove their effectiveness, so more clinical trials are needed to confirm these findings (Zhang X

There is a possibility that the imbalance of gut microbiota can damage the intestinal epithelium before UC develops, which can directly affect the intestinal permeability, so that excessive microorganisms enter the intestinal tissue and induce infection, which may lead to UC