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Abstract A comparative risk assessment of drugs including alcohol and tobacco using the margin of exposure (MOE) approach was conducted

The first smokeless non-tobacco cigarette patent was filed as early as in 1963 but no manufacturer was willing to produce this product because at that time tobacco cigarette was selling like hot cakes and those companies want to protect their market, there was no need for an alternative that might give consumers an implication that tobacco cigarette is not healthy

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McClelland's Millennium was a straight Virginia tobacco designed to be aged five years before opening in the year 2000, and all the company's Christmas Cheer renditions are well known for their aging characteristics

Courtesy of the Collection of the Columbia Museum of Art, Columbia, South Carolina