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Systemic exposure to the CYP3A-mediated metabolites 1-hydroxymidazolam and 4-hydroxymidazolam also increased (AUC inf , ~1827%) but by a smaller magnitude compared with midazolam

Among these, the most studied and understood alternative is the DEHA or di(Ethylhexyl) adipate

In more recent studies, it has been suggested that elevated epoxide hydroxylases in the brain could contribute to neuroinflammation observed in AD (Ghosh et al., 2020)

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