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Other possible risk factors include: Prior traumatic brain injuries Air pollution Lack of social connections Lack of lifelong learning Heavy alcohol use Tobacco use Poor sleep hygiene Lack of exercise Untreated cholesterol/blood pressure issues Obesity Early Stages vs

386,387,388,389 In the huge and complex neural network involving social behaviour, the PFC and its massive reciprocal loop connections constitute a top-down social behaviour regulation system

10.1021/jm900651p 77 LukaszukA.DemaegdtH.SzemenyeiE.TthG.TymeckaD.MisickaA.et al (2008)

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