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Possible clinical signs of EPI include diarrhea, vomiting, and weight loss despite an increased appetite

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In the brain, semaglutide crosses the blood-brain barrier and activates receptors in the hypothalamus and brainstem that regulate hunger, reward-seeking behavior, and food intake

NPs may activate the complement cascade, trigger hypersensitivity reactions, or induce off-target inflammatory responses, all of which can compromise patient safety

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