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Why the Glutathione Index Is the Best Indicator of Brain Oxidative Stress The GSH/GSSG ratio reflects the activity of the enzyme glutathione reductase which is responsible for the transformation of GSSG (used, oxidised) to GSH (the reduced or fully loaded form that acts as a radical scavenger)

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Therefore, the availability and use of compounds capable of interfering with exacerbated detoxification processes and ferroptosis have emerged as major assets in enabling the selective elimination of leukemia cells, while minimizing their impact on healthy ones

X., Stambas, J., Selemidis, S., Crack, P

Hit triage and validation in phenotypic screening: Considerations and strategies