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In two of the OPM-2 xenografts, BSO+L-PAM reduced tumor volumes of 1330 mm 3 and 972 mm 3 to 2), inducing CRs in majority of the mice treated (21/25), achieving MCRs in 6/25 mice, and doubling the median EFS relative to L-PAM alone ( P 80% was not cytotoxic, whereas three cell lines were affected by BSO

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Liddell, Hoepken, et al

4.2.2.2 Metabolic significance of phenylacetylglutamine Phenylacetylglutamine (PAGln) is a gut microbiota-dependent metabolite that has attracted considerable attention in recent years, formed from dietary phenylalanine metabolized by gut microbiota to phenylacetic acid and subsequently conjugated with glutamine in the liver (126)