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doi: 10.1021/acsinfecdis.0c00288 222 PotempaL

Acquired pharmacological resistance elevates the chance of recurrence (Hellinger et al

At low intracellular concentrations (0.011 M), H 2 S injects electron equivalents into the mitochondrial electron transport chain (mETC) by reducing quinone to quinol via sulphide:quinone oxidoreductase (SQR), ultimately stimulating ATP production

Cells were then washed with PBS and media replaced with low nutrient media where 2 mM glucose was substituted with equimolar concentration of 13 C-labelled glucose (D-glucose, CK Isotopes) and DMSO (0.003% v/v) control and FOXO1 inhibitor (1 M) were replenished for further 12 h until extraction

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