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Key areas of investigation include: Gastrointestinal : Demonstrated protection against NSAID-induced ulcers, inflammatory bowel disease models, and esophageal damage in multiple animal studies Musculoskeletal : Accelerated healing of transected Achilles tendons, quadriceps muscles, and medial collateral ligaments in rat models Neurological : Neuroprotective effects in models of traumatic brain injury, nerve crush injury, and dopaminergic system damage Organ protection : Hepatoprotective, cardioprotective, and nephroprotective effects demonstrated in various toxicity models The primary limitation is that all evidence comes from animal models

In a similar vein, quercetin and liraglutide have demonstrated a possible synergistic effect (Eraky, Ramadan, El-Magd, & F, 2021), while quercetin and gliclazide have demonstrated promising clinical outcomes in the treatment of diabetes (Abdelkader et al., 2020)

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A meta-analysis 52 also suggests using 18 FDG-PET to confirm disease recurrence or when the diagnosis of relapse remains unclear following standard-of-care imaging (sensitivity 90.1% and specificity 83.5%