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Specific examples of types of cancer in which RAGE expression is upregulated include colorectal cancer (32), pancreatic cancer (33), prostate cancer (34), lung cancer (35) and breast cancer, and in breast cancer, it has been reported that the RAGE rs1800624 polymorphism may increase the risk of breast cancer (36)

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On the opposite side, the saved number of interactions was lower compared with the biotin, bringing about its lower affinity to M pro while acting alone, which clarifies the pertinence of an expected relationship between the biotin and the pantothenic acid, and that could be significant in the inhibition mechanisms against M pro

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Afterwards, the extracted DNA was stored at 20 C or used immediately for PCR