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The future of PD treatment lies in the successful translation of nanomedicine from the laboratory to clinical practice, opening the way for a new era in neurological care (25)

Furthermore, intestinal epithelial cells in CD patients exhibit marked overexpression of vacuolar protein sorting 4B (VPS4B) and glycinamide ribonucleotide formyltransferase (GART), both of which modulate apoptotic processes through p38 MAPK pathway activation [55, 56]

350 However, the protective effect of high-fiber diet may be reversed if there exists colonization of Prevotella copri , which leads to the overproduction of organic acids, including fumarate and succinate, during the digestion of complex fibers and the promotion of proinflammatory responses in macrophages, exacerbating arthritis in an RA model

Previous studies have reported the favorable clinical efficacy outcomes of different concentrations of topical kojic acid formulations either alone or in conjunction with other therapeutic agents (Monteiro et al., 2013

The drug contains the phytocomplex, ie the set of active ingredients that characterize the properties of the plant, which can not be reproduced by chemical synthesis