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Xie et al., 2012)

IPD-Work Consortium

71 Interestingly, metabolite profiling of cells treated with Cu ionophore presents a time-dependent increase in the dysregulation of many TCA cycle-associated metabolites, and inhibiting the electron transport chain complexes I and II significantly reduced Cu-induced cell death

Alexandre J, Hu Y, Lu W, Pelicano H, Huang P

In addition, lysosomes also participate in this crosstalk by regulating autophagy and mitophagy, processes essential for clearing damaged organelles and maintaining cellular homeostasis (49, 50)