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doi:10.1111/acer.13108

[0529] In certain embodiment, the transmembrane domain of the CAR comprises a CD8 transmembrane domain

In the Phase 3 GAIA (CLL13) clinical trial,58 patients with CLL who were fit and had no TP53 gene abnormalities were randomized in a 1:1:1 ratio to receive six cycles of chemotherapy: one to six cycles of chemoimmunotherapy (fludarabine-cyclophosphamide-rituximab or bendamustine-rituximab) or 12 cycles of venetoclax-rituximab, venetoclax-obinutuzumab or venetoclax-obinutuzumab-ibrutinib