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Neuropsychometric assessment Although termed minimal, mHE is not trivial, having been associated with a multitude of deleterious effects on quality of life [15], including sleep disturbance [16], falls [17], ability to drive [18] and impacts on employment ability, with knock-on effects on associated socio-economic status [19]

Filtering of missing data: metabolites with more than 30% missing values across samples within a batch were removed

Mutat Res 702:123128 Ribas GS, Biancini GB, Mescka C et al (2012) Oxidative stress parameters in urine from patients with disorders of Propionate Metabolism: a beneficial effect of L-Carnitine supplementation

Crucially, they discovered a direct, measurable inverse relationship between CoQ10 levels and the severity of the patients' clinical symptomsthe lower the CoQ10 levels dropped, the more severe the patients' fatigue, autonomic dysfunction, and neurocognitive impairments became

Acta Paediatr 1995;84:93-5