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As previously reported, Pgc1- knockdown significantly decreased the mRNA levels of Ucp2 , Trx2 , Sod1 and Sod2 (Fig

Building a pathway interaction network to determine the functional dependencies between different signaling pathways may offer new perspectives on disease causes and lead to development of more effective drug formulations

The chronic use of metformin has been associated with improved cardiac function in diabetic models, linked to enhanced cardiac autophagy and better removal of damaged cellular components in heart tissue [154]