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1 Like jnorm April 15, 2026, 5:03pm #9 How do you rule out that the IP repair signature isnt just a toxic stress response to copper spiking

Abstract Aggressive and therapy-resistant cancers present a significant challenge to treatment and are associated with poor patients survival

They require a transport system known as the carnitine shuttle

Integrating ChIP-seq, HiC, and PRO-seq datasets, we revealed broad functional binding of NRF2 at enhancer elements, including NRF2-dependent enhancer-derived RNA (eRNA) synthesis and extensive linkages between NRF2 target promoters and enhancers

In contrast, HIF2 KO cells showed increased synthesis of NADH, reflected as m + 5 isotopologues, while the intracellular levels of NADH were decreased, indicating enhanced utilization of this reduced co-factor (Fig