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From the perspective of TCM, moxa sticks and moxa cones made from Artemisia argyi play an important role in the practice of traditional Chinese medical medicine, being used to treat symptoms of diseases such as arthritis, rheumatism, cold dampness, muscle soreness, and cold pain in the chest and abdomen, especially in treating the pain of patients with arthritis, rheumatism, and cold dampness

At present, although some studies have shown that inorganic selenium sources, such as sodium selenite (SS), which are mainly used as dietary selenium source additives, have significant detoxification effects on mycotoxins and heavy metal poisoning [4447], they are still limited by acute toxicity, accelerated oxidation, and low bioavailability in the application process

This heterogeneity complicates the elucidation of pharmacokinetic and pharmacodynamic profiles, particularly in compounded preparations, thereby hindering standardization and clinical validation

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demonstrated that the expression of outer membrane proteins from family 5 efflux pumps, including hefa ( HP0605 ), hefd ( HP0971 ), and hefG ( HP1327 ), was significantly greater in biofilm-forming cells than in planktonic cells (Yonezawa et al., 2019)