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doi: 10.3389/fonc.2022.993316 Received 13 July 2022 Accepted 28 July 2022 Published 22 August 2022 Volume 12 - 2022 Edited by Balkrishna Chaube, Yale University, United States Reviewed by Suyasha Roy, National Institutes of Health (NIH), United States

As illustrated in Figure 4, the gut microbiota serves as a central hub in diabetic lung injury, where gut-derived metabolites and toxins (e.g., LPS, BCAAs) remotely regulate pulmonary inflammation and immune responses through systemic circulation, ultimately leading to endothelial disruption and oxidative stress

Clynick B, Corte TJ, Jo HE, Stewart I, Glaspole IN, Grainge C, et al

Glutathione is a potent antioxidant which helps in fighting aging signs through boosting collagen production and reducing fine lines

Compared with traditional means of inactivation and attenuation, obtaining attenuated bacteria by knocking out virulence factors through genetic engineering techniques not only reduces the pathogenicity of the bacteria but also preserves their tumor-targeting properties