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ProTox-II incorporates the prediction of the various toxicities of the chemical which can be measured qualitatively as binary (active or inactive) in terms of endpoints such as acute toxicity, hepatotoxicity, carcinogenicity, immunotoxicity, mutagenicity, cytotoxicity, adverse outcome (toxicology in the twenty-first century) pathways, and toxicity targets 39

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The primary antidotes are fomepizole and ethanol (as a competitive inhibitor), both of which block the enzyme alcohol dehydrogenase, preventing toxic metabolite formation

For example, incorrectly linking intermediate dry AMD, left eye (H35.3122) to CPT code 67028 for an intravitreal injection, right eye for wet AMD, can prompt a claim rejection or a post-payment audit