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Ischemic models induce rapid oxidative damage by reperfusion-induced ROS, allowing detailed investigations into acute oxidative injury mechanisms, tissue-specific antioxidant responses, and therapeutic efficacy of antioxidants and regenerative interventions such as stem cell-derived EVs (Table 1)

Song, E.-K

Dear JW, Simpson KJ, Nicolai MP, et al

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Noteworthy, an important advancement has been recently provided in the field of cell signaling linked to amino acid sensing with the discovery that SLC38A9 is a lysosomal transporter responsible for Glutamine and Arginine flux across lysosome with consequent activation of mTOR cascade (64, 65)