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The amide group of glutamine is essential in two steps of inosine monophosphate synthesis, an intermediate in de novo purine synthesis, and in one step of uridine monophosphate synthesis, an intermediate in de novo pyrimidine synthesis (37, 38)

Manohar et al

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ATF5 contributes to sepsis-associated liver injury by promoting the accumulation of inflammatory macrophages (CD45+ CD11b+ Ly6C+) through an NF-B-dependent pathway, leading to the release of inflammatory cytokines (154)