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The biomarker approach requires analytical evaluation of (poly)phenol metabolites in biofluids to essentially reverse-trace a (poly)phenol from its end-stage metabolites towards its precursor and subsequently to its sources in food (Reference Scalbert, Brennan and Manach19)

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To determine the accumulation of nitrites, 0.3 g tomato leaves were homogenized using 50 mM glacial acetic acid (pH 3.6) in ice bath and centrifuged at 12,000 g for 15 min

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However, one small trial (11 OCD patients that were on a stable course of SSRIs) added 2 g/day EPA and found no significant improvement that was beyond placebo