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Description

J.du YanS

Sharma P, Gupta SK, Tyagi A, Khasawneh A, Akiyama H, Zal MA, Carter B, Andreeff M , Tabe Y, Borthakur G

track down the events through which the probiotic Lactobacillus GG releases soluble molecules that in turn activate the p38 MAPK pathway that synthesizes heat-shock proteins to shield the intestinal epithelial cells from damage (Tao et al., 2006)

Transpl Cell Ther

The first of these, GCLC-a (Figure 2B), would cleave after position 217, and is an exact match to P4-P1 of nsp5/6, but with an A in P1, a highly favorable residue for that position, although SCoV has a G there, and SCoV2 has an S