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It slows and impairs cognition and reaction time and the cognitive skills, impairs judgement, interferes with motor function resulting in motor incoordination, loss of balance, confusion, sedation, numbness and slurred speech, impairs memory formation, and causes sensory impairment

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For instance, decreased NAD availability can lead to compromised mitochondrial function, resulting in increased oxidative stress and neuronal damage

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The mRNA and protein expression in skeletal muscle was evaluated using Northern blot and Western blot methods after 1 month of treatment