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Whilst I appreciate that CRUK have to be very considerate in terms of any position they take, and to be cautious with any statements to that effect, I do think it would to the Public Health community at large a world of good if they were to stop focusing entirely on statistical and chemical measurements, and actually *speak* to users of these devices and see the massive difference they make to their quality of life, and factor that into their studies and positions and without wishing to get to morbid, Im sure that quality of life is something CRUK would be familiar with for many of those it works with/for, and is not something that youd discount lightly

In silico models include mathematical representations of hemodynamic changes, the mechanistic stimuli and transduction pathways in the CVS, the absorption and clearance of drugs, to name a few (Chen and Popel, in silico models to nicotine effects on fetuses are seriously lacking