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GHS-R1a is mainly Gq/11-coupled: it activates phospholipase C, generates IP3, mobilizes intracellular calcium, and triggers exocytosis

PAMs ameliorates the imiquimod-induced psoriasis-like skin disease in mice by inhibition of translocation of NF-B and production of inflammatory cytokines

Unlike traditional estrogen receptors, ERRs do not bind estrogen but instead share some target genes with estrogen receptors, hence the "estrogen-related" designation

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Some nanoparticles can sensitize effective ferroptosis, produce mild immunogenicity, and improve the response rate of non-inflammatory tumors in cancer immunotherapy [218]