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Fifty one out of sixty-five patients completed the trial, and result analysis demonstrated a significant decrease in CFS symptom scores defined by the center for disease control and prevention (CDC), and these effects were more pronounced in subjects with milder statuses of the disease

Ethics declarations Competing interests Xiu-wu Bian is the editorial board member of Signal Transduction and Targeted Therapy, but he has not been involved in the process of manuscript handling

When amphetamine accumulates in the presynaptic terminal, it collapses the vesicular pH gradient and releases vesicular monoamines into the neuronal cytosol

Generally, studies suggest a dosage ranging from 500 mg to 2000 mg per day as effective and safe