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In another double-blind, placebo-controlled trial, an improvement in cognitive performance (i.e., MMSE score) was reported in AD patients randomized to receive 800 IU/day of all - rac --tocopherol (360 mg/day of RRR --tocopherol) for six months only when the treatment effectively reduced oxidative stress (as assessed by the measure of total glutathione and markers of lipid peroxidation in the blood) (110)

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Nature 597 , 8791 (2021)

ELISA-based protein quantification indicated that LPS stimulated secretion of proinflammatory proteins including TNF-, Ccl2, and IL-6 from BV-2 cells (Fig