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Microarray studies using Affymetrix gene chips have demonstrated GHK-Cu resetting aging-related gene expression profiles in dermal fibroblasts, including upregulation of genes encoding superoxide dismutase (SOD1), metallothionein, collagen types I and III, and multiple anti-inflammatory interleukins

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Sources Lau DCW et al

Our further study showed that chronic hypoxia-induced -syn pathology promoted the hydrolytic metabolism of ceramide and decreased protein phosphatase 2A activity through activation of the hypoxia-inducible factor (HIF)-2/alkaline ceramidase (Acer)2 signaling pathway

This gap prevents dose-response relationships from animals from being translated into safe and effective design of human doses for fertility