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doi: 10.1177/0963689721997151 98 OlesenHPorsSEJensenLBGrnningAPLemserCENguyen HeimbrgerMTHet al

In a study by Frangoul et al., CRISPR-Cas9 was used to disrupt an erythroid-specific enhancer of BCL11A in CD34 + hematopoietic stem and progenitor cells (HSPCs) ( 4 Future perspectives and outlook Erythrocytes, long viewed primarily as passive oxygen carriers, are now recognized as active participants in sensing and responding to oxygen fluctuations