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Notably, TRPM8 inhibition attenuated methylglyoxal-induced mitochondrial dysfunction (MTT assay), while both TRPM8 and TRPA1 inhibition partially rescued actin depolymerization

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In 2012, the Act was revised and updated to conform to European Directive 2010/63/EU on the use of animals in science, however, this directive was already heavily based on existing UK law

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