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We also provide an update on the targets and clinical prospects of different antioxidants (melatonin, N-acetylcysteine, vitamins, -lipoic acid, mineral elements, phytochemicals, nutritional antioxidants, cytoprotectants and synthetic compounds) in the treatment of CIPN with the help of preclinical and clinical studies, emphasizing the great potential of antioxidants as adjuvant strategies to mitigate CIPN

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doi: 10.1016/0014-5793(72)80638-0, 78 OllingerR.KoglerP.TroppmairJ.HermannM.WurmM.DrascheA.et al

There are two possible mechanisms for the influence of folate and vitamin B12 deficiency on the brain: by disrupting myelination or influencing the inflammatory process [66, 67]