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As of 2025, its still in phase-3 clinical trials by Eli Lilly

Valenzuela PL, Carrera-Bastos P, Glvez BG, Ruiz-Hurtado G, Ordovas JM, Ruilope LM, et al

Eighteen hours later, cells were serum starved for 8 h, then exposed to H 2 O 2 (200 M), GW0742 (1 M), or both for 24 h, and luciferase activity was determined by Dual-Luciferase Reporter Assay System (Promega, E1910) using Promega GloMax 20/20 (Promega)

The intake of caffeine and alcohol should be tuned to the history of their usewithdrawal of these agents in a regular user may become a migraine trigger