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Cancer-associated fibroblasts (CAFs) are another TME component that plays significant roles in tumor growth, metastasis and cancer therapy resistance by secreting various growth factors like Hepatocyte growth factor (HGF) and Epidermal growth factor (EGF)

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Impaired in vivo CD4+ T cell expansion and differentiation in aged mice is not solely due to T cell defects: decreased stimulation by aged dendritic cells

In addition to the above differential gene expression, HSC1 and HSC2 expressed different levels of key secreted cytokines ( Ccl2, Ccl21 and Il32 ), chemokines ( Cxcl12 and Cxcl14 ), angiogenins ( Angptl1, Angptl2 and Angptl6 ) and mitogens ( Hgf, Hdgf, Vegfc and Pgf ) (Payen et al., 2021)

Shen, Mei-Lin, Chen-Hung Wang, Ching-Huei Lin, Ning Zhou, Shung-Te Kao, and Wu Dong Chuan