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STING Pathway Inhibition: In aging models, it has been shown to shutdown the cGAS-STING inflammatory response, protecting vital organs like the kidneys from age-related decline

Clean Vial Stoppers and Surfaces: Wipe the rubber stopper of the vial with 70% isopropanol or an alcohol swab before puncturing it with a needle

Suitable for research protocols requiring prolonged stimulation

Further considerations include: Dehydration risk : Combined effects of diarrhoea (from both Crohn's and medication) may increase dehydration risk Medication absorption : While generally minimal, delayed gastric emptying could affect absorption of oral medications with a narrow therapeutic index Monitoring requirements : Regular assessment of disease activity markers, nutritional status, and weight trends is essential Patients should be counselled about these risks and encouraged to report any worsening gastrointestinal symptoms promptly to the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk), as distinguishing between expected side effects and disease progression requires clinical expertise

Approach Loading Per-session dose 500-1,000 mg Schedule 3-5 consecutive days, then weekly/monthly Notes Clinic-supervised only