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In murine models of myocarditis, Ganoderma atrum polysaccharide (PSG) exerts cardioprotection by directly interacting with TLR4, thereby suppressing TLR4-driven oxidative stress and inflammationspecifically through inhibition of the NF-B/NLRP3 inflammasome pathway and disruption of the IRF1/VEGFA/14-3-3 signaling axis

doi:10.1016/s0140-6736(53)90327-4

Antiplatelet and anticoagulant therapy in patients with giant cell arteritis

Out of the 10% who survive past their first birthday, children go on to live fulfilling lives with significant support from their family and caretakers, as most never learn to walk or talk

Abstract Although levodopa remains the most efficacious symptomatic therapy for Parkinson disease (PD), management of levodopa treatment during the advanced stages of the disease is extremely challenging