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Further, the therapeutic potential of crocin can be validated through investigations in in vitro models of primary fibroblasts and induced pluripotent stem cells (iPSCs) derived from SCA3 patients, and in vivo models of MJD84.2 transgenic mice harboring a YAC transgene that expresses a human ATXN3 modified with SCA3-associated 84 CAG repeat expansion, and AT3q130 Caenorhabditis elegans expressing full-length ataxin-3 proteins with 130 glutamines

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Therefore, the integration of these molecular markers and related molecular mechanisms into a comprehensive assessment of biological age to counteract age-related functional decline and morbidity is increasingly becoming a hot issue of interest for scientists