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Salam MT, Islam T, Gilliland FD

Smoothing can be accomplished in a variety of ways, with splines being one of the most common and powerful

To address possible pleiotropic effects, we applied pleiotropy-robust MR methods, including MR-Egger regression, which accounts for pleiotropy when examining the association between the exposure and outcome

Pros: Clinically proven, available at pharmacies, structured quit plan, no spitting Cons: Limited flavors, medicinal taste, lower nicotine satisfaction for heavy chewers Best for: People committed to quitting nicotine entirely, following a structured tapering program Lozenges work well as a complement to other chewing tobacco alternatives

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