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In addition, age dependent accretion of dysfunctional mitochondria elevates stress level, which is exhibited by high levels oxidized products such as protein carbonyls and lipid peroxides 42

Inflammatory responses exacerbate metabolic abnormalities and form a vicious cycle

Magnetic resonance spectroscopy (MRS) allows the insight into their pathophysiology through exploration of a range of biochemicals putatively relevant to aetiological processes, in particular mitochondrial dysfunction and energy metabolism

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Plla T, Mirzahosseini A, Noszl B (2020) Species-Specific, pH-Independent, Standard Redox Potential of Selenocysteine and Selenocysteamine