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Periodontal EDS (pEDS) is characterized by severe and intractable periodontitis of early onset (childhood or adolescence), lack of attached gingiva, pretibial plaques, and family history of a first-degree relative who meets clinical criteria Cardiac-valvular EDS (cvEDS) is characterized by severe progressive cardiac-valvular problems (aortic valve, mitral valve), skin problems (hyperextensibility, atrophic scars, thin skin, easy bruising), and joint hypermobility (generalized or restricted to small joints)

2019;25(3):43243e6

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Research history of metal ions in neurodegenerative diseases As early as 1924, iron deposition was first observed in the globus pallidus (GP) of PD patients through Perls and Turnbull staining (Fig

Even mild or subclinical thyroid dysfunction can have profound effects on conception, pregnancy outcomes, and postpartum recoveryyet it's often overlooked in conventional care