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Hypoxia and the regulation of mitogen-activated protein kinases: gene transcription and the assessment of potential pharmacologic therapeutic interventions

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For instance, with respect to the effect on nucleus pulposus cells (NPCs), m 6 A-mediated methylation by abnormally elevated METTL3 enhances the stability and expression of SIAH1 mRNA, which targets and ubiquitinates XIAP, promoting aging and apoptosis [192]

Moreover, existing studies predominantly emphasize therapeutic outcomes, often sidelining varied effects

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